General Description of Digestive System
After having a meal, our digestive system breaks the large complex food particles into simpler
smaller particles by enzymatic actions. These enzymes are proteins that combine with the
substrates (food particles) and form products, for example, in the digestive system, the
formation of glucose from bread part of meal. These glucose molecules are directly absorbed
into our blood circulatory system through the small intestine, which is part of our digestive
system. As our body is made up of cells, each and every cell of the body absorbs this glucose as
per its requirement directly from the bloodstream. After entry into the cell, the breakdown of
glucose (glycolysis) occurs again by enzymes present in the cells. The products of glycolysis
(glucose breakdown) enter into the mitochondria (an organelle present inside the cell). Here, in
the mitochondria, further breakdown occurs which ultimately produces molecules of ATP
(Adenosine triphosphate). ATP acts as energy currency of our cells. All the cells activities e.g.
growth, maintenance, synthesis, movements, etc. carried out by this ATP.
Action of NSAIDs
If you have a headache or joint pain and are feeling discomfort, you're likely to pick up an NSAID
(non-steroidal anti-inflammatory drug) for relief. NSAIDs are medicines that are widely used to
relieve pain and reduce inflammation. NSAIDs act as enzyme inhibitors. NSAIDs bind with the
active site of enzymes in place of substrates and block the function of these enzymes. In that
case, they slow or inhibit the formation of those chemicals which cause inflammation or induce
pain. For example, when an injury occurs, the body produces a chemical called prostaglandin.
This chemical plays an important function in the body's inflammatory response. But the
production of this chemical is inhibited by NSAIDs. Enzymes that form this chemical are blocked
by NSAID drugs. As a result, NSAIDs reduce pain and inflammation by blocking the activities of
the enzyme.
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